Institut Polytechnique de Paris
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Engineering for Health Interdisciplinary Center (E4H)

An interdisciplinary research center to shape the future of life sciences and health and to address key societal challenges.
Engineering for Health Interdisciplinary Center (E4H)

Our society is undergoing a revolution that will fundamentally redefine our approach to the biological sciences and to medicine. This revolution is enabled by the convergence of an array of technologies and medical and social practices that offer unprecedented opportunities for innovative approaches to medical practice and to life science research. The vision driving the Engineering for Health (E4H) Center of Institut Polytechnique de Paris (IP Paris) is that seizing these opportunities and realizing their full potential requires a highly interdisciplinary approach where quantitative and social scientists collaborate closely with the life science and medical communities.

Key figures

  • 5 Engineering IP Paris schools
  • 10 IP Paris departments
  • 23 Laboratories
  • 250 Research and support staff
  • 5 Scientific and technological platforms
  • 6 Specialized study tracks

Mission

The goal of the Engineering for Health (E4H) Interdisciplinary Research Center is to leverage IP Paris’ strengths in the physical, mathematical, and social sciences towards a highly quantitative and interdisciplinary approach to the life sciences and medicine. We wish to foster a dynamic environment where basic and translational research continuously feed off of one another to address major societal challenges in health and well-being.

How we accomplish our mission

  • The E4H Center plays an integral role in fostering research, training, and innovation. IP Paris has significant strengths and world-class research activities in interdisciplinary life science research with more than 100 faculty members and their teams from all ten IP Paris academic departments pursuing a broad range of fundamental and applied studies. The existing research and training programs within the IP Paris community provide a unique opportunity for tackling key societal challenges and associated grand scientific questions through a highly interdisciplinary approach. By focusing on research aimed at understanding, imaging, modeling, predicting, and engineering living systems and by creating a strongly-knit community, the E4H Center serves to significantly amplify the global scientific impact of IP Paris research in this area.
  • A critical mission of the E4H Center is the training and mentoring of young scientists. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts not only many of France’s top students and young scientists but also outstanding students and postdoctoral fellows from around the world. The E4H Center is affiliated with the Interdisciplinary Biology, Biomedical Engineering, and Mathematics for Living Systems PhD programs (graduate school and PhD Track) and thus provides state-of-the-art training in fields critical for life sciences and health.
  • IP Paris is an ideal environment for innovation, technology transfer, and translational research with a fully staffed technology transfer office and a startup incubator and accelerator on campus. New fully equipped space and laboratories are available for students, startup companies, and industrial partners working on various bioengineering design and development projects. Ongoing collaborations with clinicians and partner institutes provide ample opportunities for translational research, most notably in personalized (patient-specific) therapies, medical device design and development, and connected health products.

Founding members

        

Research in the E4H Center spans the spectrum of highly fundamental studies all the way to applied and translational investigations. It also spans a wide spectrum of scales ranging from the molecular to the population level. Our research activities can be broadly categorized as follows:

Development of a fundamental quantitative understanding of living systems, including prokaryotes, and ranging from the molecular to the macroscopic scales. This includes biochemistry and biophysics of biomolecules, genomics and transcriptomics, basic principles in cell and developmental biology and biophysics, and systems biology and physiology.

Imaging molecules, cells, tissues, and whole organisms using a variety of imaging modalities including NMR, crystallography, and electron microscopy. A particular campus strength is the development of novel approaches in biophotonics and advanced optical imaging techniques (super-resolution, in-depth, high-throughput, and multimodal). Cellular/molecular imaging as well as genomic/proteomic studies generate large amounts of data, thereby creating considerable opportunities in data science, machine/deep learning, quantification, and analysis.

Multiscale modeling approaches focusing on molecular modeling of RNA and protein structure, in silico design of therapeutic molecules, and modeling of the structure and function of various organs and multi-organ systems in health and disease. In parallel, mathematical approaches in population dynamics are applied towards a predictive framework for the emergence of zoonoses and pathogen mutations.

Knowledge gained from the first three research directions above serves as a basis for translational activities in biomedical engineering. An example is the development of organ-on-chip/disease-on-chip systems that are used for designing therapeutic molecules/vaccines and for screening drugs. Particular emphasis is placed on emerging threats (e.g. viruses and antibiotic resistance) as well as personalized medicine (individual patient monitoring, ‘omic’ approaches, bioinformatics, machine learning, and predictive modeling). Synthetic biology, which encompasses methodologies from various disciplines including biophysics, chemical and biological engineering, and computer science, is used as a basis for  designing new biological systems and interfacing with novel biomedical devices.

A critical mission of the E4H Center is the training and mentoring of young scientists at the doctoral and postdoctoral levels. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts many of France’s top engineering students as well as excellent doctoral students and postdoctoral fellows from around the world with strong and rigorous training in the physical and mathematical sciences. A significant fraction of these bright young scientists are interested in applying their skills to the life sciences and healthcare fields. The E4H Center  provides the ideal training and mentoring environment for these scientists.

Our training courses

Whether you are a researcher, a student, or working for a start-up or a company, you will find in this space all the resources (infrastructure, equipment, software, expertise) that the E4H centre offers you to carry out your experimental projects.

The E4H Interdisciplinary Centre supports your biomedical engineering projects through calls for projects:

Serge Schoen New Synergies Grant Program

Deadline: February 16, 2025

Medical Fellows Program

Deadline: January 13, 2025

Postdoctoral Fellowship Program

Deadline: January 13, 2025

BME Student International Experience Program

Permanent call (see deadlines)

BME Conference Fellowships Program

Permanent call (see deadlines)

BME Design Projects

Closed on September 20, 2024

BME Pedagogical Seed Grants

Closed on May 12, 2024

BME Seed Grants

Call closed on April 18, 2023

To keep up to date with job and internship offers from the IP Paris life sciences and health community and its partners in France and abroad, subscribe to our newsletter:

> Subscribe

  • Abdul Barakat, Scientific Co-Director
  • Jean-Louis Mergny, Scientific Co-Director
  • Silvia Corsini, Chief Operation Officer
  • Delphine L'Huillier, Administrative and financial Officer
  • Joni Frederick, E4H Platform Manager
  • Benoît Monégier du Sorbier, Communication and Partnerships Manager
  • Abdul Barakat, École polytechnique
  • Jean-Louis Mergny, École polytechnique
  • Jocelyne Arquembourg, Télécom Paris
  • Elsa Angelini, Télécom Paris
  • Jerome Boudy, Télécom SudParis
  • Dominique Chapelle, Inria, École polytechnique
  • Philippe Choné, ENSAE
  • Jean Boisson, ENSTA Paris
  • François Hache, École polytechnique
  • Sylvie Méléard, École polytechnique
  • Anne Chantal Gouget, École polytechnique
  • Angelo Pierangelo, École polytechnique
  • Yann Ponty, École polytechnique

Logo E4H Horizontal Noir

Engineering for Health
X Novation Center, École polytechnique
Avenue Coriolis
91120 Palaiseau

About

Our society is undergoing a revolution that will fundamentally redefine our approach to the biological sciences and to medicine. This revolution is enabled by the convergence of an array of technologies and medical and social practices that offer unprecedented opportunities for innovative approaches to medical practice and to life science research. The vision driving the Engineering for Health (E4H) Center of Institut Polytechnique de Paris (IP Paris) is that seizing these opportunities and realizing their full potential requires a highly interdisciplinary approach where quantitative and social scientists collaborate closely with the life science and medical communities.

Key figures

  • 5 Engineering IP Paris schools
  • 10 IP Paris departments
  • 23 Laboratories
  • 250 Research and support staff
  • 5 Scientific and technological platforms
  • 6 Specialized study tracks

Mission

The goal of the Engineering for Health (E4H) Interdisciplinary Research Center is to leverage IP Paris’ strengths in the physical, mathematical, and social sciences towards a highly quantitative and interdisciplinary approach to the life sciences and medicine. We wish to foster a dynamic environment where basic and translational research continuously feed off of one another to address major societal challenges in health and well-being.

How we accomplish our mission

  • The E4H Center plays an integral role in fostering research, training, and innovation. IP Paris has significant strengths and world-class research activities in interdisciplinary life science research with more than 100 faculty members and their teams from all ten IP Paris academic departments pursuing a broad range of fundamental and applied studies. The existing research and training programs within the IP Paris community provide a unique opportunity for tackling key societal challenges and associated grand scientific questions through a highly interdisciplinary approach. By focusing on research aimed at understanding, imaging, modeling, predicting, and engineering living systems and by creating a strongly-knit community, the E4H Center serves to significantly amplify the global scientific impact of IP Paris research in this area.
  • A critical mission of the E4H Center is the training and mentoring of young scientists. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts not only many of France’s top students and young scientists but also outstanding students and postdoctoral fellows from around the world. The E4H Center is affiliated with the Interdisciplinary Biology, Biomedical Engineering, and Mathematics for Living Systems PhD programs (graduate school and PhD Track) and thus provides state-of-the-art training in fields critical for life sciences and health.
  • IP Paris is an ideal environment for innovation, technology transfer, and translational research with a fully staffed technology transfer office and a startup incubator and accelerator on campus. New fully equipped space and laboratories are available for students, startup companies, and industrial partners working on various bioengineering design and development projects. Ongoing collaborations with clinicians and partner institutes provide ample opportunities for translational research, most notably in personalized (patient-specific) therapies, medical device design and development, and connected health products.

Founding members

        

Research in the E4H Center spans the spectrum of highly fundamental studies all the way to applied and translational investigations. It also spans a wide spectrum of scales ranging from the molecular to the population level. Our research activities can be broadly categorized as follows:

Development of a fundamental quantitative understanding of living systems, including prokaryotes, and ranging from the molecular to the macroscopic scales. This includes biochemistry and biophysics of biomolecules, genomics and transcriptomics, basic principles in cell and developmental biology and biophysics, and systems biology and physiology.

Imaging molecules, cells, tissues, and whole organisms using a variety of imaging modalities including NMR, crystallography, and electron microscopy. A particular campus strength is the development of novel approaches in biophotonics and advanced optical imaging techniques (super-resolution, in-depth, high-throughput, and multimodal). Cellular/molecular imaging as well as genomic/proteomic studies generate large amounts of data, thereby creating considerable opportunities in data science, machine/deep learning, quantification, and analysis.

Multiscale modeling approaches focusing on molecular modeling of RNA and protein structure, in silico design of therapeutic molecules, and modeling of the structure and function of various organs and multi-organ systems in health and disease. In parallel, mathematical approaches in population dynamics are applied towards a predictive framework for the emergence of zoonoses and pathogen mutations.

Knowledge gained from the first three research directions above serves as a basis for translational activities in biomedical engineering. An example is the development of organ-on-chip/disease-on-chip systems that are used for designing therapeutic molecules/vaccines and for screening drugs. Particular emphasis is placed on emerging threats (e.g. viruses and antibiotic resistance) as well as personalized medicine (individual patient monitoring, ‘omic’ approaches, bioinformatics, machine learning, and predictive modeling). Synthetic biology, which encompasses methodologies from various disciplines including biophysics, chemical and biological engineering, and computer science, is used as a basis for  designing new biological systems and interfacing with novel biomedical devices.

A critical mission of the E4H Center is the training and mentoring of young scientists at the doctoral and postdoctoral levels. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts many of France’s top engineering students as well as excellent doctoral students and postdoctoral fellows from around the world with strong and rigorous training in the physical and mathematical sciences. A significant fraction of these bright young scientists are interested in applying their skills to the life sciences and healthcare fields. The E4H Center  provides the ideal training and mentoring environment for these scientists.

Our training courses

Whether you are a researcher, a student, or working for a start-up or a company, you will find in this space all the resources (infrastructure, equipment, software, expertise) that the E4H centre offers you to carry out your experimental projects.

The E4H Interdisciplinary Centre supports your biomedical engineering projects through calls for projects:

Serge Schoen New Synergies Grant Program

Deadline: February 16, 2025

Medical Fellows Program

Deadline: January 13, 2025

Postdoctoral Fellowship Program

Deadline: January 13, 2025

BME Student International Experience Program

Permanent call (see deadlines)

BME Conference Fellowships Program

Permanent call (see deadlines)

BME Design Projects

Closed on September 20, 2024

BME Pedagogical Seed Grants

Closed on May 12, 2024

BME Seed Grants

Call closed on April 18, 2023

To keep up to date with job and internship offers from the IP Paris life sciences and health community and its partners in France and abroad, subscribe to our newsletter:

> Subscribe

  • Abdul Barakat, Scientific Co-Director
  • Jean-Louis Mergny, Scientific Co-Director
  • Silvia Corsini, Chief Operation Officer
  • Delphine L'Huillier, Administrative and financial Officer
  • Joni Frederick, E4H Platform Manager
  • Benoît Monégier du Sorbier, Communication and Partnerships Manager
  • Abdul Barakat, École polytechnique
  • Jean-Louis Mergny, École polytechnique
  • Jocelyne Arquembourg, Télécom Paris
  • Elsa Angelini, Télécom Paris
  • Jerome Boudy, Télécom SudParis
  • Dominique Chapelle, Inria, École polytechnique
  • Philippe Choné, ENSAE
  • Jean Boisson, ENSTA Paris
  • François Hache, École polytechnique
  • Sylvie Méléard, École polytechnique
  • Anne Chantal Gouget, École polytechnique
  • Angelo Pierangelo, École polytechnique
  • Yann Ponty, École polytechnique

Logo E4H Horizontal Noir

Engineering for Health
X Novation Center, École polytechnique
Avenue Coriolis
91120 Palaiseau