Institut Polytechnique de Paris
Ecole Polytechnique ENSTA ENSAE Télécom Paris Télécom SudParis

Master Year 2 Molecular Chemistry and Interfaces

Master Year 2 Molecular Chemistry and Interfaces
Year

Master Year 2

Program

Molecular Chemistry and Interfaces

ECTS Credits

60

Language

English/French

Duration of the Course

12 months, full time

Orientation

Research

Location

Palaiseau Campus

Course duration

12 months, full time

Course start

September

Degree awarded

Master’s Degree

WHY ENROLL IN THIS PROGRAM?

Asset n° 1 

Pursue a PhD

Asset n°2

Strengthen your research skills with a 6 month-research project

Asset n°3

Deepen your understanding of molecular chemistry and interfaces

The Molecular Chemistry and Interfaces (MOCHI) Master’s program is a high-level scientific and academic program offered by the Institut Polytechnique de Paris and the Université Paris Saclay. It is devoted to molecular chemistry and its applications in the fields of biology and material sciences.

The program delivers state-of-the-art knowledge in academic sciences and brings students closer to applications in industry. In order to reach a better understanding, students will be given access to molecular modelling tools.

The courses focus on organometallic chemistry and catalysis, supramolecular chemistry, chemobiology, and chemistry for optoelectronics. Delivered in English, the program also includes a literature and total synthesis project, as well as a 6-month research project.

Objectives

The program aims to:

  • Provide high-level learning in molecular chemistry to train tomorrow’s experts
  • Enable students to build complex molecules, understand and propose reaction mechanisms
  • Provide a program at the interface of biology, materials sciences, optoelectronics to imagine new applications and collaborations
  • Provide students with in-depth understanding using molecular modelling

After graduation, students will be able to work:

  • As a research scientist in academia or industry (after a PhD in molecular sciences), R&D engineer or project manager in chemistry
  • In key employment sectors like the pharmaceutical industry, agrochemical industry, cosmetics, petrochemistry, consulting and patent application

This information and courses listed below are for 20202-2021.

The information will be updated during the first quarter of 2021.

6 optional modules of 6 ECTS, 32 hours courses+ 8 hours exercises for each module.

Exam conditions: written exams for all modules (first and second session). 

Students will have to choose 5 out of 6 for their training: 

 

  • Advanced organic chemistry :

This module focuses on several advanced methods and topics in modern organic chemistry, which will be introduced and developed along the following three courses: “Photochemical Organic Reactions”, “Main-Group Chemistry: P, B, Si, S”; and “Asymmetric Synthesis”. After a careful presentation of general concepts, various important applications of photochemical reactions, asymmetric methods (including catalytic processes) and synthetic methods based on the chemistry of main-group elements of the p-block (mainly B, Si, P, S) will be reviewed, predominantly in organic synthesis, with occasional illustrations in organometallic chemistry.

Teaching: J. Hannedouche (CNRS, Paris-Saclay), D. Bourissou  (X), D. Aitken (Paris-Saclay)

  • Organometallic Chemistry and Catalysis

This module mainly focuses on the organometallic chemistry and its application in catalysis. The rationalization of the activation of substrates/bonds by metal complexes will be presented as well as the synthesis and reactivity of a variety of carbanionic organometallic reagents. Traditional and more recent aspect of metal based catalysis will be disclosed, with a special attention to coupling reactions catalyzed by palladium or non-noble metals: scope, mechanistic aspects, advantages and limitations will be presented. The role of advanced catalysis concerning the necessary change of paradigm in the production of major chemicals, from fossil to renewable feedstocks will be addressed.

Teaching: Y. Six (X), C. Gosmini (X), A. Auffrant (X), T. Cantat (X), N. Mézailles (X)

 

  • Chemistry and Biology

This module focuses on the interfaces between chemistry and biology, mainly through the following four courses: bioinorganic Chemistry, chemical biology, biopolymers and photocontrol of biological processes. Metalloproteins, electron transfer systems and oxygen transportation/activation, and the study of their chemical mimics will be described. After introduction to biopolymers and their main chemical properties, bioconjugation and bioorthogonal chemistry will be presented with cases studies in in vivo protein fluorescent labeling and target identification, as well as enzymatic activity detection. Caged compounds and photoswitchable bioactive molecules, the rapidly developing field, will also be introduced with cases studies on examples and study of research articles on the caged (bio)molecules and photopharmacology. The objectives of this module are to give an overview about the wide research field of chemical biology via the description of important biological processes involving biopolymers like (metallo)proteins, polysaccharides, polynucleotides; and to illustrate how chemists may develop new tools for the field.

Teaching: F. Avenier (Paris-Saclay), Joanne Xie (ENS  Paris-Saclay), P.Y. Renard (Univ Rouen), B. Vauzeilles (CNRS, Paris-Saclay)

 

  • Chemistry for optoelectronics

The module aims at giving an overview of application of molecular chemistry in the field of optoelectronic devices. The module is divided into three sections:
1- Conducting molecular materials

2- From molecules to optoelectronic devices.
3- Switchable molecular materials


The module aims at showing how molecular materials can be designed to achieve a particular function in optoelectronic devices: energy harvesting, photon to charge conversion, optical or magnetic properties switching,…Various types of materials (polymers, nanoparticles, inorganic…) as wells as molecules (donor-acceptor, dyads, dyes…) will be browsed and relations between molecular structures and properties will be highlighted.

Teaching: G. Zucchi (X), I Yassar (X), F. Miomandre (ENS Saclay), K. Nakatani (ENS Paris-Saclay), T. Mallah (Paris-Saclay), N. Avarvari (X), P. Audebert (ENS Saclay)

 

  • Supramolecular, Macromolecular and Material Chemistry

This module focuses on the interfaces between chemistry and material sciences, mainly through the following three courses: Supramolecular Chemistry, Supramolecular Polymer Chemistry, Chemistry of hybrid organic/inorganic materials. The concepts, interactions and classes of molecules (porphyrins, macrocycles…) involved in supramolecular assemblies will be presented together with applications in the field of medecine and environmental sciences. The module will further present recent trends in the field of polymer chemistry with a particular focus on biological polymers, preparation and applications of copolymers as well as supramolecular polymers and gelators. Finally, concepts and tools for the functionalization of various hybrid organic/inorganic materials will be presented. Examples will be selected to demonstrate how these tools may allow to tune the desired properties of the material.

Teaching: L. Bouteiller (X), G. Nocton (X), D. Carmichael (X), T. Gacoin (X), N. Bogliotti (ENS Paris-Saclay)

 

  • Molecular modelling

This module provides an introduction to molecular modelling from basic principles to applications to complex molecules. It is divided into two parts. In the first, the basics of modelling based on the laws of classical mechanics are introduced: force fields, Monte Carlo sampling and molecular dynamics. Applications to free energy calculations and various approaches of solvation are described. Illustrations span a wide range of molecules and macromolecules in chemistry and biochemistry. The second part is devoted to the analysis of quantum chemical calculations (based on density functional theory) to understand molecular properties and reactivity in organic and organometallic chemistry. Various analyses of electron density and atomic indices are introduced and their application to chemical reactivity is described. The first objective of this module is to give the Master students an overview about some of the main methods in molecular modelling with enough background to understand their potential and application domains. The second objective is to understand how to translate a chemical problem into a modelling workflow, through the hands-on use of research softwares and work on a personal project.

Teaching: F. Cailliez (Paris-Saclay), C. Clavaguéra (CNRS, Paris-Saclay), G. Frison (X), G. Ohanessian (X)

 

  • Project 1 : Retrosynthesis and synthetic planning: practice in total synthesis

This module aims at teaching students how to start and solve a challenging synthetic problem. An introduction on retrosynthetic analysis will first be given, recalling Corey's and Seebach's logics and the main rules to be applied. Then, after a few examples of applications aiming at showing the diversity of approaches, synthetic problems will be proposed, discussed and possibly debated. The students will have to work by themselves at solving these problems, with a final examination consisting in a short written proposal of the synthetic problem (retrosynthesis + total synthesis forward) and defence of this proposal.

Teaching: B. Nay (X), 3 ECTS, (8 hours teaching)

 

  • Project 2: literature project

The literature project is a bibliographical study that will have to be performed on a subject close to the following research internship. It will be the occasion of a written report and oral defense performed before the beginning of the research internship.

2 ECTS (all teachers involved)

Five to six months research project performed in industry or academia, in France or abroad, starting from the end of January.

Admission requirements

Academic prerequisites

  • Completion of the first year of a Master’s program in Chemistry at Institut Polytechnique de Paris or equivalent in France or abroad

Language prerequisites

English

How to apply

Applications can be submitted exclusively online. You will need to provide the following documents:

  • Transcript
  • Two academic references (added online directly by your referees)
  • CV/resume
  • Statement of purpose

You will receive an answer in your candidate space within 2 months of the closing date for the application session.

Fees and scholarships

  • EU/EEA/Switzerland students: 243€
  • Non-EU/EEA/Switzerland students: 3770€
  • Engineer students enrolled in one of the five member schools of Institut Polytechnique de Paris (Ecole polytechnique, ENSTA Paris, ENSAE Paris, Télécom Paris and Télécom SudParis): 159€
  • Special cases: please refer to the "Cost of studies" section of the FAQs

Find out more about scholarships

Applications and admission dates

Description

The Molecular Chemistry and Interfaces (MOCHI) Master’s program is a high-level scientific and academic program offered by the Institut Polytechnique de Paris and the Université Paris Saclay. It is devoted to molecular chemistry and its applications in the fields of biology and material sciences.

The program delivers state-of-the-art knowledge in academic sciences and brings students closer to applications in industry. In order to reach a better understanding, students will be given access to molecular modelling tools.

The courses focus on organometallic chemistry and catalysis, supramolecular chemistry, chemobiology, and chemistry for optoelectronics. Delivered in English, the program also includes a literature and total synthesis project, as well as a 6-month research project.

Objectives

The program aims to:

  • Provide high-level learning in molecular chemistry to train tomorrow’s experts
  • Enable students to build complex molecules, understand and propose reaction mechanisms
  • Provide a program at the interface of biology, materials sciences, optoelectronics to imagine new applications and collaborations
  • Provide students with in-depth understanding using molecular modelling

After graduation, students will be able to work:

  • As a research scientist in academia or industry (after a PhD in molecular sciences), R&D engineer or project manager in chemistry
  • In key employment sectors like the pharmaceutical industry, agrochemical industry, cosmetics, petrochemistry, consulting and patent application

This information and courses listed below are for 20202-2021.

The information will be updated during the first quarter of 2021.

6 optional modules of 6 ECTS, 32 hours courses+ 8 hours exercises for each module.

Exam conditions: written exams for all modules (first and second session). 

Students will have to choose 5 out of 6 for their training: 

 

  • Advanced organic chemistry :

This module focuses on several advanced methods and topics in modern organic chemistry, which will be introduced and developed along the following three courses: “Photochemical Organic Reactions”, “Main-Group Chemistry: P, B, Si, S”; and “Asymmetric Synthesis”. After a careful presentation of general concepts, various important applications of photochemical reactions, asymmetric methods (including catalytic processes) and synthetic methods based on the chemistry of main-group elements of the p-block (mainly B, Si, P, S) will be reviewed, predominantly in organic synthesis, with occasional illustrations in organometallic chemistry.

Teaching: J. Hannedouche (CNRS, Paris-Saclay), D. Bourissou  (X), D. Aitken (Paris-Saclay)

  • Organometallic Chemistry and Catalysis

This module mainly focuses on the organometallic chemistry and its application in catalysis. The rationalization of the activation of substrates/bonds by metal complexes will be presented as well as the synthesis and reactivity of a variety of carbanionic organometallic reagents. Traditional and more recent aspect of metal based catalysis will be disclosed, with a special attention to coupling reactions catalyzed by palladium or non-noble metals: scope, mechanistic aspects, advantages and limitations will be presented. The role of advanced catalysis concerning the necessary change of paradigm in the production of major chemicals, from fossil to renewable feedstocks will be addressed.

Teaching: Y. Six (X), C. Gosmini (X), A. Auffrant (X), T. Cantat (X), N. Mézailles (X)

 

  • Chemistry and Biology

This module focuses on the interfaces between chemistry and biology, mainly through the following four courses: bioinorganic Chemistry, chemical biology, biopolymers and photocontrol of biological processes. Metalloproteins, electron transfer systems and oxygen transportation/activation, and the study of their chemical mimics will be described. After introduction to biopolymers and their main chemical properties, bioconjugation and bioorthogonal chemistry will be presented with cases studies in in vivo protein fluorescent labeling and target identification, as well as enzymatic activity detection. Caged compounds and photoswitchable bioactive molecules, the rapidly developing field, will also be introduced with cases studies on examples and study of research articles on the caged (bio)molecules and photopharmacology. The objectives of this module are to give an overview about the wide research field of chemical biology via the description of important biological processes involving biopolymers like (metallo)proteins, polysaccharides, polynucleotides; and to illustrate how chemists may develop new tools for the field.

Teaching: F. Avenier (Paris-Saclay), Joanne Xie (ENS  Paris-Saclay), P.Y. Renard (Univ Rouen), B. Vauzeilles (CNRS, Paris-Saclay)

 

  • Chemistry for optoelectronics

The module aims at giving an overview of application of molecular chemistry in the field of optoelectronic devices. The module is divided into three sections:
1- Conducting molecular materials

2- From molecules to optoelectronic devices.
3- Switchable molecular materials


The module aims at showing how molecular materials can be designed to achieve a particular function in optoelectronic devices: energy harvesting, photon to charge conversion, optical or magnetic properties switching,…Various types of materials (polymers, nanoparticles, inorganic…) as wells as molecules (donor-acceptor, dyads, dyes…) will be browsed and relations between molecular structures and properties will be highlighted.

Teaching: G. Zucchi (X), I Yassar (X), F. Miomandre (ENS Saclay), K. Nakatani (ENS Paris-Saclay), T. Mallah (Paris-Saclay), N. Avarvari (X), P. Audebert (ENS Saclay)

 

  • Supramolecular, Macromolecular and Material Chemistry

This module focuses on the interfaces between chemistry and material sciences, mainly through the following three courses: Supramolecular Chemistry, Supramolecular Polymer Chemistry, Chemistry of hybrid organic/inorganic materials. The concepts, interactions and classes of molecules (porphyrins, macrocycles…) involved in supramolecular assemblies will be presented together with applications in the field of medecine and environmental sciences. The module will further present recent trends in the field of polymer chemistry with a particular focus on biological polymers, preparation and applications of copolymers as well as supramolecular polymers and gelators. Finally, concepts and tools for the functionalization of various hybrid organic/inorganic materials will be presented. Examples will be selected to demonstrate how these tools may allow to tune the desired properties of the material.

Teaching: L. Bouteiller (X), G. Nocton (X), D. Carmichael (X), T. Gacoin (X), N. Bogliotti (ENS Paris-Saclay)

 

  • Molecular modelling

This module provides an introduction to molecular modelling from basic principles to applications to complex molecules. It is divided into two parts. In the first, the basics of modelling based on the laws of classical mechanics are introduced: force fields, Monte Carlo sampling and molecular dynamics. Applications to free energy calculations and various approaches of solvation are described. Illustrations span a wide range of molecules and macromolecules in chemistry and biochemistry. The second part is devoted to the analysis of quantum chemical calculations (based on density functional theory) to understand molecular properties and reactivity in organic and organometallic chemistry. Various analyses of electron density and atomic indices are introduced and their application to chemical reactivity is described. The first objective of this module is to give the Master students an overview about some of the main methods in molecular modelling with enough background to understand their potential and application domains. The second objective is to understand how to translate a chemical problem into a modelling workflow, through the hands-on use of research softwares and work on a personal project.

Teaching: F. Cailliez (Paris-Saclay), C. Clavaguéra (CNRS, Paris-Saclay), G. Frison (X), G. Ohanessian (X)

 

  • Project 1 : Retrosynthesis and synthetic planning: practice in total synthesis

This module aims at teaching students how to start and solve a challenging synthetic problem. An introduction on retrosynthetic analysis will first be given, recalling Corey's and Seebach's logics and the main rules to be applied. Then, after a few examples of applications aiming at showing the diversity of approaches, synthetic problems will be proposed, discussed and possibly debated. The students will have to work by themselves at solving these problems, with a final examination consisting in a short written proposal of the synthetic problem (retrosynthesis + total synthesis forward) and defence of this proposal.

Teaching: B. Nay (X), 3 ECTS, (8 hours teaching)

 

  • Project 2: literature project

The literature project is a bibliographical study that will have to be performed on a subject close to the following research internship. It will be the occasion of a written report and oral defense performed before the beginning of the research internship.

2 ECTS (all teachers involved)

Five to six months research project performed in industry or academia, in France or abroad, starting from the end of January.

Admission requirements

Academic prerequisites

  • Completion of the first year of a Master’s program in Chemistry at Institut Polytechnique de Paris or equivalent in France or abroad

Language prerequisites

English

How to apply

Applications can be submitted exclusively online. You will need to provide the following documents:

  • Transcript
  • Two academic references (added online directly by your referees)
  • CV/resume
  • Statement of purpose

You will receive an answer in your candidate space within 2 months of the closing date for the application session.

Fees and scholarships

  • EU/EEA/Switzerland students: 243€
  • Non-EU/EEA/Switzerland students: 3770€
  • Engineer students enrolled in one of the five member schools of Institut Polytechnique de Paris (Ecole polytechnique, ENSTA Paris, ENSAE Paris, Télécom Paris and Télécom SudParis): 159€
  • Special cases: please refer to the "Cost of studies" section of the FAQs

Find out more about scholarships

Applications and admission dates