Engineering for Health Interdisciplinary Center (E4H)
Our society is undergoing a revolution that will fundamentally redefine our approach to the biological sciences and to medicine. This revolution is enabled by the convergence of an array of technologies and medical and social practices that offer unprecedented opportunities for innovative approaches to medical practice and to life science research. The vision driving the Engineering for Health (E4H) Center of Institut Polytechnique de Paris (IP Paris) is that seizing these opportunities and realizing their full potential requires a highly interdisciplinary approach where quantitative and social scientists collaborate closely with the life science and medical communities.
Key figures
- 5 Engineering IP Paris schools
- 10 IP Paris departments
- 23 Laboratories
- 250 Research and support staff
- 5 Scientific and technological platforms
- 6 Specialized study tracks
Mission
The goal of the Engineering for Health (E4H) Interdisciplinary Research Center is to leverage IP Paris’ strengths in the physical, mathematical, and social sciences towards a highly quantitative and interdisciplinary approach to the life sciences and medicine. We wish to foster a dynamic environment where basic and translational research continuously feed off of one another to address major societal challenges in health and well-being.
How we accomplish our mission
- The E4H Center plays an integral role in fostering research, training, and innovation. IP Paris has significant strengths and world-class research activities in interdisciplinary life science research with more than 100 faculty members and their teams from all ten IP Paris academic departments pursuing a broad range of fundamental and applied studies. The existing research and training programs within the IP Paris community provide a unique opportunity for tackling key societal challenges and associated grand scientific questions through a highly interdisciplinary approach. By focusing on research aimed at understanding, imaging, modeling, predicting, and engineering living systems and by creating a strongly-knit community, the E4H Center serves to significantly amplify the global scientific impact of IP Paris research in this area.
- A critical mission of the E4H Center is the training and mentoring of young scientists. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts not only many of France’s top students and young scientists but also outstanding students and postdoctoral fellows from around the world. The E4H Center is affiliated with the Interdisciplinary Biology, Biomedical Engineering, and Mathematics for Living Systems PhD programs (graduate school and PhD Track) and thus provides state-of-the-art training in fields critical for life sciences and health.
- IP Paris is an ideal environment for innovation, technology transfer, and translational research with a fully staffed technology transfer office and a startup incubator and accelerator on campus. New fully equipped space and laboratories are available for students, startup companies, and industrial partners working on various bioengineering design and development projects. Ongoing collaborations with clinicians and partner institutes provide ample opportunities for translational research, most notably in personalized (patient-specific) therapies, medical device design and development, and connected health products.
Founding members
Research in the E4H Center spans the spectrum of highly fundamental studies all the way to applied and translational investigations. It also spans a wide spectrum of scales ranging from the molecular to the population level. Our research activities can be broadly categorized as follows:
Development of a fundamental quantitative understanding of living systems, including prokaryotes, and ranging from the molecular to the macroscopic scales. This includes biochemistry and biophysics of biomolecules, genomics and transcriptomics, basic principles in cell and developmental biology and biophysics, and systems biology and physiology.
Imaging molecules, cells, tissues, and whole organisms using a variety of imaging modalities including NMR, crystallography, and electron microscopy. A particular campus strength is the development of novel approaches in biophotonics and advanced optical imaging techniques (super-resolution, in-depth, high-throughput, and multimodal). Cellular/molecular imaging as well as genomic/proteomic studies generate large amounts of data, thereby creating considerable opportunities in data science, machine/deep learning, quantification, and analysis.
Multiscale modeling approaches focusing on molecular modeling of RNA and protein structure, in silico design of therapeutic molecules, and modeling of the structure and function of various organs and multi-organ systems in health and disease. In parallel, mathematical approaches in population dynamics are applied towards a predictive framework for the emergence of zoonoses and pathogen mutations.
Knowledge gained from the first three research directions above serves as a basis for translational activities in biomedical engineering. An example is the development of organ-on-chip/disease-on-chip systems that are used for designing therapeutic molecules/vaccines and for screening drugs. Particular emphasis is placed on emerging threats (e.g. viruses and antibiotic resistance) as well as personalized medicine (individual patient monitoring, ‘omic’ approaches, bioinformatics, machine learning, and predictive modeling). Synthetic biology, which encompasses methodologies from various disciplines including biophysics, chemical and biological engineering, and computer science, is used as a basis for designing new biological systems and interfacing with novel biomedical devices.
A critical mission of the E4H Center is the training and mentoring of young scientists at the doctoral and postdoctoral levels. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts many of France’s top engineering students as well as excellent doctoral students and postdoctoral fellows from around the world with strong and rigorous training in the physical and mathematical sciences. A significant fraction of these bright young scientists are interested in applying their skills to the life sciences and healthcare fields. The E4H Center provides the ideal training and mentoring environment for these scientists.
- 1 PhD Track: Bioengineering and Quantitative Life Sciences
- 4 Masters: Biology and Health, Biomedical Engineering, Mechanical Engineering for Clinicians (MECENCLI) and Mathematics for Living Systems
- Specialized Engineer Diploma: General engineer in digital health track
The Bioengineering and Quantitative Life Sciences PhD Track is a 5-year integrated Master’s/PhD program that provides highly interdisciplinary research-intensive training. The program is open to outstanding students from a variety of scientific backgrounds who have completed their undergraduate training with highest honors and who are interested in tackling cutting-edge research in this field using a multidisciplinary approach. This program enables selected students to benefit from the first-class IP Paris ecosystem and to be closely associated with the research activities carried out in the Institute's laboratories from the first year of the Master's program. Each student benefits from individual and personalized supervision by a faculty member. Attractive funding packages are provided to top students.
The first two years of the program, leading to the Master's degree, are designed to enable students to acquire the tools necessary for the successful completion of an ambitious research project, supervised by an academic tutor.
The following three years are entirely dedicated to the student’s doctoral research project and lead to the PhD degree from the Institut Polytechnique de Paris.
Students apply to one of the following three tracks:
- Mathematics for Living Systems – typically targeted for students with previous training in pure or applied mathematics
- Biomedical Engineering – typically targeted for students with previous training in engineering, physics, or chemistry
- Biology and Interfaces - typically targeted for students with previous training in the biological sciences
This Master’s program is dedicated to molecular and cellular biology. It maintains a strong link between reductive molecular and structural approaches, as well as between more integrated approaches of cell biology/organism development and new therapeutic strategies.
This multidisciplinary program looks at progress in biology (observation, sequencing, synthesis of the genome and omic approaches) through dialog with other disciplines including physics, chemistry, mathematics, computer science and mechanics. It also deals with ethical questions concerning bio-technological applications. The program includes courses focusing on biological concepts and disciplinary interfaces, as well as an internship in a research laboratory.
The Biomedical Engineering: Biomechanics & Biophysics (BME) Master’s program provides students with state-of-the-art training in the exciting field of biomedical engineering. Applicants are expected to have strong backgrounds in engineering, physics, or applied mathematics and a desire to contribute to the upcoming revolutionary changes in the life sciences and medicine. No background in biology is necessary. Students have the opportunity to specialize in various subfields of biomedical engineering includiing imaging, biomaterials, biophysics & biomechanics, and sensors & devices.
| The Biomedical Engineering: Biomechanics & Biophysics (BME) Master’s program is funded by a Ecole Universitaire de Recherche fund as part of the France 2030 plan. |
|
The Mechanical Engineering for clinicians (MECENCLI) master’s program is a joint program between Institut Polytechnique de Paris and the Université de Paris Cité, intended for clinicians. The program combines advanced academic knowledge in mechanics with long-term clinical research projects. MECENCLI prepares graduates for doctoral studies, which are essential for an academic career in medicine, or for industrial research and development positions.
The Mathematics for Life Sciences (MSV) master's program is a complete and structured training in the mathematical fields at the interface with the life sciences (biology, medicine, ecology). Its originality lies in its mathematical roots, the breadth of the spectrum of common mathematical skills acquired by graduates, and the variety of specializations that are offered. Interaction with biologists, ecologists or medical doctors is encouraged through the completion of an annual project, attendance of regular seminars, and a six month research internship.
This program is offered to Telecom SudParis engineering students. At the forefront of digital-related research, Telecom SudParis researchers are interested in major public health issues through the prism of new technologies.
Bio-imaging, diagnostic assistance, human-machine interfaces, neurosciences, televigilance, virtual reality, connected objects, data security, etc., Telecom SudParis specialists strive to put digital technology at the service of medicine and human well-being. These research activities are intended to feed and irrigate the projects and curricula of the school's offering in health sciences.
The program:
- Training of expert digital engineers familiar with health topics
- Benefiting from an e-health ecosystem bringing together schools, health professionals, industry and public authorities
- Centered on a “by design” approach, considering the user from the design of the technological solution
- Multidisciplinary: from technology to applications, including socio-economic and ethical aspects
- Transversal: addressing human health and well-being, following an ecosystem approach
The E4H Interdisciplinary Centre supports your biomedical engineering projects through calls for projects:
BME Student International Experience Program | Permanent call (see deadlines) |
BME Conference Fellowships Program | Permanent call (see deadlines) |
Serge Schoen New Synergies Grant Program | Deadline: May 12, 2024 |
BME Pedagogical Seed Grants | Deadline: May 12, 2024 |
Medical Fellows Program | Closed on January 15, 2024 |
Postdoctoral Fellowship Program | Closed on January 15, 2024 |
BME Design Projects | Call closed on Sept. 18, 2023 |
BME Seed Grants | Call closed on April 18, 2023 |
| 14 Mai 2024 | Rencontres Innovation Santé #2 |
| 22 mars 2024 | Inauguration of the BME Student Club of IP Paris |
| 30 November 2023 | Rencontres Innovation Santé #1 |
| 9 novembre 2023 | Séminaire : Approches interdisciplinaires face aux résistances aux antimicrobiens |
| 5 July 2023 | Annual Forum E4H |
| 13 April 2023 | Biomedical Engineer Master Open Day |
| 14 March 2023 | Symposium on Engineering for Cardiovascular Health |
| 17 February 2023 | Lancement du LivingLab |
| 11 october 2022 | Workshop: Current Trends in Cancer Modeling and Research |
| 7 July 2022 | E4H Annual Forum |
Retrouvez dans cet espace les offres d'emploi ou de stage proposées par le Centre E4H ou ses partenaires.
Ingénieur-e expérimentation et instrumentation biologiques pour le Centre E4H
CDD - 6 mois
Published on 30/06/2023
Chargé.e de communication du Centre E4H
Alternance - 1 ans
Published on 21/04/2023
Separating Healthy from Pathological Patterns in Neuroimaging
Post-Doctorat - 2 ans
Published on 07/04/2023
Biomedical engineering applied to antimicrobial resistance (AMR)
Post-Doctorat - 2 ans
Published on 07/04/2023
- Abdul Barakat, Scientific Co-Director
- Jean-Louis Mergny, Scientific Co-Director
- Silvia Corsini, Chief Operation Officer
- Delphine L'Huillier, Administrative and financial Officer
- Joni Frederick, E4H Platform Manager
- Benoît Monégier du Sorbier, Communication and Partnerships Manager
- Abdul Barakat, École polytechnique
- Jean-Louis Mergny, École polytechnique
- Jocelyne Arquembourg, Télécom Paris
- Elsa Angelini, Télécom Paris
- Jerome Boudy, Télécom SudParis
- Dominique Chapelle, Inria, École polytechnique
- Philippe Choné, ENSAE
- Jean Boisson, ENSTA Paris
- François Hache, École polytechnique
- Sylvie Méléard, École polytechnique
- Anne Chantal Gouget, École polytechnique
- Angelo Pierangelo, École polytechnique
- Yann Ponty, École polytechnique
Engineering for Health
X Novation Center, École polytechnique
Avenue Coriolis
91120 Palaiseau
Our society is undergoing a revolution that will fundamentally redefine our approach to the biological sciences and to medicine. This revolution is enabled by the convergence of an array of technologies and medical and social practices that offer unprecedented opportunities for innovative approaches to medical practice and to life science research. The vision driving the Engineering for Health (E4H) Center of Institut Polytechnique de Paris (IP Paris) is that seizing these opportunities and realizing their full potential requires a highly interdisciplinary approach where quantitative and social scientists collaborate closely with the life science and medical communities.
Key figures
- 5 Engineering IP Paris schools
- 10 IP Paris departments
- 23 Laboratories
- 250 Research and support staff
- 5 Scientific and technological platforms
- 6 Specialized study tracks
Mission
The goal of the Engineering for Health (E4H) Interdisciplinary Research Center is to leverage IP Paris’ strengths in the physical, mathematical, and social sciences towards a highly quantitative and interdisciplinary approach to the life sciences and medicine. We wish to foster a dynamic environment where basic and translational research continuously feed off of one another to address major societal challenges in health and well-being.
How we accomplish our mission
- The E4H Center plays an integral role in fostering research, training, and innovation. IP Paris has significant strengths and world-class research activities in interdisciplinary life science research with more than 100 faculty members and their teams from all ten IP Paris academic departments pursuing a broad range of fundamental and applied studies. The existing research and training programs within the IP Paris community provide a unique opportunity for tackling key societal challenges and associated grand scientific questions through a highly interdisciplinary approach. By focusing on research aimed at understanding, imaging, modeling, predicting, and engineering living systems and by creating a strongly-knit community, the E4H Center serves to significantly amplify the global scientific impact of IP Paris research in this area.
- A critical mission of the E4H Center is the training and mentoring of young scientists. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts not only many of France’s top students and young scientists but also outstanding students and postdoctoral fellows from around the world. The E4H Center is affiliated with the Interdisciplinary Biology, Biomedical Engineering, and Mathematics for Living Systems PhD programs (graduate school and PhD Track) and thus provides state-of-the-art training in fields critical for life sciences and health.
- IP Paris is an ideal environment for innovation, technology transfer, and translational research with a fully staffed technology transfer office and a startup incubator and accelerator on campus. New fully equipped space and laboratories are available for students, startup companies, and industrial partners working on various bioengineering design and development projects. Ongoing collaborations with clinicians and partner institutes provide ample opportunities for translational research, most notably in personalized (patient-specific) therapies, medical device design and development, and connected health products.
Founding members
Research in the E4H Center spans the spectrum of highly fundamental studies all the way to applied and translational investigations. It also spans a wide spectrum of scales ranging from the molecular to the population level. Our research activities can be broadly categorized as follows:
Development of a fundamental quantitative understanding of living systems, including prokaryotes, and ranging from the molecular to the macroscopic scales. This includes biochemistry and biophysics of biomolecules, genomics and transcriptomics, basic principles in cell and developmental biology and biophysics, and systems biology and physiology.
Imaging molecules, cells, tissues, and whole organisms using a variety of imaging modalities including NMR, crystallography, and electron microscopy. A particular campus strength is the development of novel approaches in biophotonics and advanced optical imaging techniques (super-resolution, in-depth, high-throughput, and multimodal). Cellular/molecular imaging as well as genomic/proteomic studies generate large amounts of data, thereby creating considerable opportunities in data science, machine/deep learning, quantification, and analysis.
Multiscale modeling approaches focusing on molecular modeling of RNA and protein structure, in silico design of therapeutic molecules, and modeling of the structure and function of various organs and multi-organ systems in health and disease. In parallel, mathematical approaches in population dynamics are applied towards a predictive framework for the emergence of zoonoses and pathogen mutations.
Knowledge gained from the first three research directions above serves as a basis for translational activities in biomedical engineering. An example is the development of organ-on-chip/disease-on-chip systems that are used for designing therapeutic molecules/vaccines and for screening drugs. Particular emphasis is placed on emerging threats (e.g. viruses and antibiotic resistance) as well as personalized medicine (individual patient monitoring, ‘omic’ approaches, bioinformatics, machine learning, and predictive modeling). Synthetic biology, which encompasses methodologies from various disciplines including biophysics, chemical and biological engineering, and computer science, is used as a basis for designing new biological systems and interfacing with novel biomedical devices.
A critical mission of the E4H Center is the training and mentoring of young scientists at the doctoral and postdoctoral levels. By virtue of its outstanding academic reputation and its highly selective admissions process, IP Paris attracts many of France’s top engineering students as well as excellent doctoral students and postdoctoral fellows from around the world with strong and rigorous training in the physical and mathematical sciences. A significant fraction of these bright young scientists are interested in applying their skills to the life sciences and healthcare fields. The E4H Center provides the ideal training and mentoring environment for these scientists.
- 1 PhD Track: Bioengineering and Quantitative Life Sciences
- 4 Masters: Biology and Health, Biomedical Engineering, Mechanical Engineering for Clinicians (MECENCLI) and Mathematics for Living Systems
- Specialized Engineer Diploma: General engineer in digital health track
The Bioengineering and Quantitative Life Sciences PhD Track is a 5-year integrated Master’s/PhD program that provides highly interdisciplinary research-intensive training. The program is open to outstanding students from a variety of scientific backgrounds who have completed their undergraduate training with highest honors and who are interested in tackling cutting-edge research in this field using a multidisciplinary approach. This program enables selected students to benefit from the first-class IP Paris ecosystem and to be closely associated with the research activities carried out in the Institute's laboratories from the first year of the Master's program. Each student benefits from individual and personalized supervision by a faculty member. Attractive funding packages are provided to top students.
The first two years of the program, leading to the Master's degree, are designed to enable students to acquire the tools necessary for the successful completion of an ambitious research project, supervised by an academic tutor.
The following three years are entirely dedicated to the student’s doctoral research project and lead to the PhD degree from the Institut Polytechnique de Paris.
Students apply to one of the following three tracks:
- Mathematics for Living Systems – typically targeted for students with previous training in pure or applied mathematics
- Biomedical Engineering – typically targeted for students with previous training in engineering, physics, or chemistry
- Biology and Interfaces - typically targeted for students with previous training in the biological sciences
This Master’s program is dedicated to molecular and cellular biology. It maintains a strong link between reductive molecular and structural approaches, as well as between more integrated approaches of cell biology/organism development and new therapeutic strategies.
This multidisciplinary program looks at progress in biology (observation, sequencing, synthesis of the genome and omic approaches) through dialog with other disciplines including physics, chemistry, mathematics, computer science and mechanics. It also deals with ethical questions concerning bio-technological applications. The program includes courses focusing on biological concepts and disciplinary interfaces, as well as an internship in a research laboratory.
The Biomedical Engineering: Biomechanics & Biophysics (BME) Master’s program provides students with state-of-the-art training in the exciting field of biomedical engineering. Applicants are expected to have strong backgrounds in engineering, physics, or applied mathematics and a desire to contribute to the upcoming revolutionary changes in the life sciences and medicine. No background in biology is necessary. Students have the opportunity to specialize in various subfields of biomedical engineering includiing imaging, biomaterials, biophysics & biomechanics, and sensors & devices.
| The Biomedical Engineering: Biomechanics & Biophysics (BME) Master’s program is funded by a Ecole Universitaire de Recherche fund as part of the France 2030 plan. |
|
The Mechanical Engineering for clinicians (MECENCLI) master’s program is a joint program between Institut Polytechnique de Paris and the Université de Paris Cité, intended for clinicians. The program combines advanced academic knowledge in mechanics with long-term clinical research projects. MECENCLI prepares graduates for doctoral studies, which are essential for an academic career in medicine, or for industrial research and development positions.
The Mathematics for Life Sciences (MSV) master's program is a complete and structured training in the mathematical fields at the interface with the life sciences (biology, medicine, ecology). Its originality lies in its mathematical roots, the breadth of the spectrum of common mathematical skills acquired by graduates, and the variety of specializations that are offered. Interaction with biologists, ecologists or medical doctors is encouraged through the completion of an annual project, attendance of regular seminars, and a six month research internship.
This program is offered to Telecom SudParis engineering students. At the forefront of digital-related research, Telecom SudParis researchers are interested in major public health issues through the prism of new technologies.
Bio-imaging, diagnostic assistance, human-machine interfaces, neurosciences, televigilance, virtual reality, connected objects, data security, etc., Telecom SudParis specialists strive to put digital technology at the service of medicine and human well-being. These research activities are intended to feed and irrigate the projects and curricula of the school's offering in health sciences.
The program:
- Training of expert digital engineers familiar with health topics
- Benefiting from an e-health ecosystem bringing together schools, health professionals, industry and public authorities
- Centered on a “by design” approach, considering the user from the design of the technological solution
- Multidisciplinary: from technology to applications, including socio-economic and ethical aspects
- Transversal: addressing human health and well-being, following an ecosystem approach
The E4H Interdisciplinary Centre supports your biomedical engineering projects through calls for projects:
BME Student International Experience Program | Permanent call (see deadlines) |
BME Conference Fellowships Program | Permanent call (see deadlines) |
Serge Schoen New Synergies Grant Program | Deadline: May 12, 2024 |
BME Pedagogical Seed Grants | Deadline: May 12, 2024 |
Medical Fellows Program | Closed on January 15, 2024 |
Postdoctoral Fellowship Program | Closed on January 15, 2024 |
BME Design Projects | Call closed on Sept. 18, 2023 |
BME Seed Grants | Call closed on April 18, 2023 |
| 14 Mai 2024 | Rencontres Innovation Santé #2 |
| 22 mars 2024 | Inauguration of the BME Student Club of IP Paris |
| 30 November 2023 | Rencontres Innovation Santé #1 |
| 9 novembre 2023 | Séminaire : Approches interdisciplinaires face aux résistances aux antimicrobiens |
| 5 July 2023 | Annual Forum E4H |
| 13 April 2023 | Biomedical Engineer Master Open Day |
| 14 March 2023 | Symposium on Engineering for Cardiovascular Health |
| 17 February 2023 | Lancement du LivingLab |
| 11 october 2022 | Workshop: Current Trends in Cancer Modeling and Research |
| 7 July 2022 | E4H Annual Forum |
Retrouvez dans cet espace les offres d'emploi ou de stage proposées par le Centre E4H ou ses partenaires.
Ingénieur-e expérimentation et instrumentation biologiques pour le Centre E4H
CDD - 6 mois
Published on 30/06/2023
Chargé.e de communication du Centre E4H
Alternance - 1 ans
Published on 21/04/2023
Separating Healthy from Pathological Patterns in Neuroimaging
Post-Doctorat - 2 ans
Published on 07/04/2023
Biomedical engineering applied to antimicrobial resistance (AMR)
Post-Doctorat - 2 ans
Published on 07/04/2023
- Abdul Barakat, Scientific Co-Director
- Jean-Louis Mergny, Scientific Co-Director
- Silvia Corsini, Chief Operation Officer
- Delphine L'Huillier, Administrative and financial Officer
- Joni Frederick, E4H Platform Manager
- Benoît Monégier du Sorbier, Communication and Partnerships Manager
- Abdul Barakat, École polytechnique
- Jean-Louis Mergny, École polytechnique
- Jocelyne Arquembourg, Télécom Paris
- Elsa Angelini, Télécom Paris
- Jerome Boudy, Télécom SudParis
- Dominique Chapelle, Inria, École polytechnique
- Philippe Choné, ENSAE
- Jean Boisson, ENSTA Paris
- François Hache, École polytechnique
- Sylvie Méléard, École polytechnique
- Anne Chantal Gouget, École polytechnique
- Angelo Pierangelo, École polytechnique
- Yann Ponty, École polytechnique
Engineering for Health
X Novation Center, École polytechnique
Avenue Coriolis
91120 Palaiseau
