Researchers from the Institut Polytechnique de Paris contributed to a study demonstrating the role of DNA structures in gene regulation
08 Aug. 2025
Researchers from the Ecole Polytechnique's Optics and Biosciences Laboratory (LOB*) participated in a study published in Nature Genetics demonstrating the role of G-quadruplexes in regulating gene expression in mammals.
The role of G-quadruplexes in transcription ©Cyril Esnault
G-quadruplexes are special three-dimensional structures in DNA that effectively pave the way for the enzymatic machinery of transcription, the first step in gene expression. G-quadruplexes are present in 40% of gene promoters and provide new insights into these DNA sequences that initiate transcription.
*LOB: a joint research unit CNRS, Inserm, École Polytechnique, Institut Polytechnique de Paris, 91120 Palaiseau, France